Borgo Il Melone dates back to the beginning of the 19th century when it was a property of the Mancinis, a noble family from Cortona who still owns the entire set of buildings. The Mancini family boasts a wide family tree that includes Girolamo Mancini, scholar, man of letters and patriot who followed Garibaldi in 1860 and 1866.

He is the author of memorable biographies, such as "Life of Luca Signorelli", "Life of Lorenzo Valla", "Life of L.B. Alberti", and of dissertations such as "Cortona in the Middle Ages" and "Writes and Codices from Cortona".

He was Gonfalonier in Cortona; he was elected Member of the Parliament twice, and was Librarian and Lucumon of the Etruscan Academy. In 1881 he founded the bank 'Banca Popolare Cortona'.